Hi,
I just purchased Anomaly on the Mac App Store and the game seems to be a lot of graphics issues.
On first run the game crashed. On second run, the initial sequence was black screen with audio in background. Then the menu appeared that looked a bit odd. Once I am in game the screen has red dots floating around, and some circles and I am told to select an intersection but the screen is mostly black and there is nothing to select. I've closed the game and run it numerous times, each time seems to show something a little different.
There are screenshots at this URL:
http://leighmcculloch.com/anomaly/My Mac is a: MacBookPro2,2, Intel Core 2 Duo 2.33 GHz, 3GB Memory, ATI Radeon X1600. It's a little old, but it still plays all the latest Valve Steam games like HL2, etc, so I'd expect it should be able to play Anomaly. I set it on Lowest graphics even, and still the same problems.