City Hospital will instantly turn hostile on a character before you even enter the hospital. This first happened to me with Arica (and I suspected it was a bug since I had aggroed the hospital with Arica in a previous run). Then I saw the same bug happen to my friend streaming on Twitch using Pavle.
How to reproduce:
In playthrough 1, go aggro the hospital with a character (ie. Pavle) by stealing something in plain sight, attacking guard, etc.
Start a new playthrough, and get the same character (ie. Pavle)
In playthrough 2, return to hospital with that same character (ie. Pavle). You will be shot on sight.